TSC1 anticorps (pSer505) (AbBy Fluor® 750)

N° du produit ABIN5012017

L’anticorps Lapin Polyclonal anti-TSC1 a été validé pour WB, IF (cc) et IF (p). Il convient pour détecter TSC1 dans des échantillons de Humain, Souris et Mouton.

Aperçu rapide pour TSC1 anticorps (pSer505) (AbBy Fluor® 750) (ABIN5012017)

Antigène: TSC1 (Tuberous Sclerosis 1 (TSC1))

Reactivité: Humain, Souris, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TSC1 est conjugé à/à la AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-TSC1 anticorps (AbBy Fluor® 750)

Épitope: pSer505

Réactivité croisée: Humain, Souris, Mouton

Homologie: Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human TSC1 around the phosphorylation site of Ser505 [FD(p-S)PF]

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur TSC1

Antigène: TSC1 (Tuberous Sclerosis 1 (TSC1))

Autre désignation: TSC1

Sujet:

Synonyms: TSC1phospho S505, LAM, TSC1, Tuberous sclerosis 1 protein.

Background: Hamartin, or TSC1, is a suspected tumor suppressor implicated in the disease tuberous sclerosis 1. It is a negative regulator of cell division controlling the transition from G0/G1 to S phase, and it seems to act through the phosphatidylinositol 3 kinase/Akt pathway. TSC1 interacts with tuberin m(TSC2), which is thought to be a GAP (GTPase Activating Protein) for the Rap1 and Rab5 small G Proteins. The Hamartin/Tuberin complex has been shown to inhibit mTor. Hamartin has also been shown to interact with ERM (Ezrin-Radixin-Moesin) proteins and with F-actin, suggesting a role for TSC proteins in modulation of cell adhesion and morphology.

ID gène: 7248

Pathways: Signalisation RTK, AMPK Signaling, Regulation of Cell Size, Tube Formation